Showing posts with label NanoTox. Show all posts
Showing posts with label NanoTox. Show all posts

Monday, December 08, 2008

Putting the tech back into nano

Almost five years ago, in my NanoBot post, Nanotubes and the tale of the rats, I discussed an often-cited Dupont study on the toxicity of carbon nanotubes, the material that will either build us an elevator to the stars or turn into the "next asbestos," depending on whose propaganda you want to believe.

ratIt was a study around which the anti-nanotech movement was built, since at the time it was the only one around that looked at the potential health effects of carbon nanotubes. I questioned whether pumping a rat's lungs full of nanotubes until he suffocated to death really proved anything.

Now, a new study published in the journal Nanotoxicology indeed shows that if you send a nanotube into a cell functionalized with the proper material and in the proper dosage, it does no damage. Increase the dosage, and damage occurs.

This is a point I've been trying to make for years on this blog. Nanotech is not about use of nanoscale materials only. It's also about engineering them to do what you need them to do. Right now, we're only in the beginning stages. Like I wrote back in January 2004:

This is how science works. Small steps, each study building on the conclusions of others. Nanotubes might, as the slogan goes these days, turn out to be the "next asbestos," but it is far too early to convict them of anything except being in the wrong rats at the wrong time.

Backgrounder
Nanotubes and the tale of the rats
Nanotech? Nahh, doesn't exist yet

Tuesday, October 21, 2008

How PR 'spins' the atom

Here's an excellent piece by my colleague Alex Schmidt, who explains why "nano" is not appearing in the fine print on product packages these days.

A few years ago, plenty of companies hopped on the “nano” bandwagon, using the word in advertisements and product names. In some cases, the word "nano" was used to brand products that didn’t even contain nano-scale particles! Apparently, marketers imagined that the word would trickle into the mainstream to mean something vaguely cool, mysterious and futuristic. But those vague associations don't make for a particularly meaningful branding concept. You may have bought the iPod nano, but probably not because of its name.

Now PR folks have gone so far as to invent a new investment sector for companies that use nanotechnology: Cleantech. It’s a word meant to suggest an innovative, environmentally friendly product that won’t be associated with “nano” if it loses its good name. More here.

Alex is an excellent radio and print journalist who, like me, discovered the hard way that it's tough to sell a nanotech-themed story to the mainstream media because after all the hype and the scare-mongering are weeded out, real nanotech is, well, kind of hard to wrap your brain around. So, the stories that see print and make the airwaves are the ones that focus on dreams or nightmares. Or, like Alex's story, how companies choose to "spin" their atoms.

I spoke with Alex sometime last year, when she was attempting to sell her piece. She wrote to me about how publications that are already biased for or against nanotech development are the ones that are most likely to buy a nano story.

"These are the only types of magazines that will cover nano, because they're the only ones willing to be completely biased on the topic," she said. "That is, other publications that are more level-headed would never cover the topic because the "gray area" truth about nanotechnology just isn't sexy enough."

Higher journalistic standards, it seems, brings out those "gray areas" and make for a less-sexy story with no definitive conclusions about whether nano is "good or bad."

One national publication killed her story outright after a frustrating back-and-forth with an editor. Why? Well, to paraphrase her editor: It was not as provocative as it could have been and he became confused about what nanotechnology really is. There was no central thesis over whether we should worry about nanotech or not.

In short, it was killed because nanotech is still, essentially, a basic science story with an awful lot of hype, fear, hope and hucksterism surrounding it.

She sounded a lot like me after having covered nanotech a few years longer than she has.

"I reported the *&^% out of my piece and feel I have lots of good info in my head at this point," she said.

I know. I know. Maybe we'll start a support group.

But with The New Plastic, Alex, you done good.

Backgrounder
The Case Of God v. Nanotech
Cleantech's the new nano; nano's the new dot-bomb

Thursday, August 30, 2007

Serious nanotox reporting, for a change

nanotoxFor those who are interested in the issues surrounding nanotechnology and toxicity, but would like to get beyond the bumper-sticker pseudoscience of the anti-sunscreen crowd, the relatively new journal of Nanotoxicology sounds like a worthwhile read. The publication just came out with its second issue.

Well, I can't actually, um, read it since I can't afford the $164.45 subscription rate (now, if it were only $164.42, then perhaps I could bust open the piggy bank for it), but I'm sure someone out there will fill me in. Although I'm sure this journal lacks the side-splitting humor of the recent Friends of the Earth anti-sunscreen manifesto (pdf), I'm sure Nanotoxicology makes up for it in serious scholarship.

Backgrounder
Truth is stranger than prediction
UK sets up a fragmented nanopolicy
Made-up science attacks makeup
Nano is a concept by which we measure our pain

Saturday, August 18, 2007

Made-up science attacks makeup

The Angry Toxicologist says: "... don't eat your sunscreen. Good advice anytime."

Thank you, AT. At last, an answer from a pro to the "Friends of the Earth" use of made-up science to attack nanotech in sunscreen.

Backgrounder
FDA should put in more face time
Friends of the Earth releases nanotox report
Truth is stranger than prediction

Friday, July 13, 2007

Spread some jelly on your quantum dots

"Jelly Dots:" They're shinier than regular ol' quantum dots, plus they're less toxic. (The following sentence is to be read aloud in the style of Homer Simpson) MMmmmmmmm ... shiiinyyy ... less toxic ... jelllyyyy dotttss ... yummmm ...

Backgroun-Doh!
Taking toxicity out of quantum dots
The Springfield Syndrome

Thursday, June 21, 2007

Great Nano Chicken *

Nanotech Nervousness (Environment Report)

Researchers are studying whether nano-sized material could purge bacteria from the digestive tracts of poultry. The bacteria doesn't harm chickens and turkeys, but it can make people sick. The hope is that using nanoparticles could reduce the use of antibiotics in poultry. More here

* Apologies to Ed Regis

Thursday, May 18, 2006

Listen up, class: Let the facts interfere with your nanotox story

I may be an irresponsible blogger, or whatever, but I'm 40 years old and learned the craft on a manual typewriter from some old-school journalism mentors. If you cut me open, I bleed ink and not pixels.

So, that said, Journalism 101: If the premise of the story is in doubt -- that the "Magic Nano" recall is not really an example of what could go wrong with nanotech products, since there is likely no nanotech in the product -- then you need to change the focus of your story.

Let me repeat this in a clearer way, class. Let facts interfere with a good story.

It's frustrating to read and hear some of the coverage of this "story," since basic rules of journalism are apparently thrown out the window. Science and technology writers, especially, should know that there have actually been no tests showing that nanotechnology is toxic to anything or anyone. The old nanotube rat and buckyball fish studies show that if you pump these beasts full of raw nanoparticles, they'll probably suffocate or become brain damaged.

Any company that dumps a bunch of raw, uncooked, unengineered nanoparticles into any product would not actually be practicing "nanotechnology." So, these oft-repeated studies show absolutely nothing about the potential toxicity of nanotech products. They show that scientists are practicing science, one small step at a time.

Backgrounder
Nanotubes and the tale of the rats
A little story about drugs, bass and balls
Nano is a concept by which we measure our pain
How low can nano go?
Groups call for moratorium on nano-named products
Are nanoparticle studies 'one decade late'?

Monday, July 19, 2004

Are nanoparticle studies 'one decade late'?


ETC Group Executive Director Pat Mooney, in a recent paper discussing nanotechnology regulatory issues, brings up a reasonable point:

    “Ironically, governments are talking about the need to be proactive, failing to admit that they’re at least one decade late: nanotech products are already commercially available and laboratory workers and consumers are already being exposed to nanoparticles that could pose serious risks to people and the environment.”

It's a question I've posed to a handful of nanotech government, business and academic leaders over the past few years, including Sean Murdock, head of the NanoBusiness Alliance; and Kevin Ausman, executive director of the Center for Biological and Environmental Nanotechnology at Rice University.

Here's what I asked Ausman:

    Lovy: Do you think this is developing the way it should? At the same time you're studying the health and environmental effects of this stuff, nanotubes are being churned out. Do you think the industry is developing faster than the research into the impact?

    Kevin Ausman: I think that the technology is developing faster than the impact research. I think that, however, the technology for any new field normally develops faster than the impact research. And compared to that normal curve, we're ahead of it. We are developing impact research far ahead of where you would expect it to happen.

And here's a snippet of my late-2003 interview with Murdock in Chicago, when he was still executive director of regional nano group AtomWorks. I knew at the time that he was a likely successor for NanoBusiness Alliance co-founder Mark Modzelewski and asked my questions with this in mind.

    Lovy: I asked the same question of Kevin Ausman: Do you think the business of nanotech is progressing faster than the research into its risks? Do you think it's progressing the way it should? Titanium dioxide (nanoparticles) has been out there since 1995. Now, CBEN is studying its effects in various situations. Fullerenes are being produced in Japan right now. CBEN is studying their effects now. Is it too late?

    Sean Murdock: Let me disaggregate that. Some things you can test for in advance. Some things you can only test as you see products used. Sometimes products are used in unexpected ways … but it's hard to know what those are until you start to have a product in use until see how people are using it. So, that's what I'm saying. It's the type of risk that we're talking about.

    Do I think there should be research that's ongoing in terms of the effects of nanoparticles on toxicity. Yes, I think that's at CBEN, I that's happening elsewhere. In the grand scheme of things, it's not like we have megatons of production of nanoparticles that are getting dispersed all over the world right now. Is there some production that's taking place? Yes.

    Lovy: Are you saying it's a nonissue today, or an overblown issue?

    Murdock: No, I'm saying it's an issue that we need to look at, balance and try to assess. I'm saying that the way that some people have tried to create fear around it, that it could kill us all and do that kind of thing, doesn't reflect the rate at which these things can propagate.

    Lovy: But is the study of environmental and health effects of nanomaterials almost an afterthought?

    Murdock: No, I would strongly disagree there because it was embedded within the NNI (National Nanotechnology Initiative) plan from the outset. There was a societal and ethical implications workshop back in 2000.

    Lovy: Do you think groups like CBEN would have received as much funding and attention now had the alarm not been sounded by groups like ETC and Greenpeace? Do you think that they fired an opening shot that forced the issue sooner than in might have otherwise been dealt with?

    Murdock: I don't know that it forced the issue sooner than it would have been dealt with. People looked at this and said, "Look, there are some issues with AgBioTech, we didn't manage the public, didn't think about unintended consequences and we're going to manage it proactively. We're going to be on top of it." The design, from the outset, of the NNI recognized that and had intended to draw these issues. Now, if you're asking, "Has it heightened attention on the issue?" The CBEN (grant) was awarded before ETC Group came out with anything.

NanoBot Backgrounder
Safety and health group launches nano page
Nano's 'No GMO' Mantra
Meet the new nanoboss

Tuesday, June 29, 2004

Ruff on the environment


thurston_1   thurston_2


My dog, Thurston, is a collar-carrying member of the Green Party. Yesterday, he was pawing through the latest issue of Utne Reader, which contained a short article informing its readers of the now-ritualistic leftist line that buckyballs are bad (just as "war is peace, freedom is slavery and ignorance is strength"). Thurston, being a mutt of passion, bounded out to the yard, grabbed his exact-replica buckyball model (the first toy I bought for him as a puppy) and decided to "save the fish" by tearing it apart.

I tried to intervene. I told him that I, too, am concerned about the environment and that I'm also a liberal, yet the party line is totally wrong on this one -- confusing the possible cure for another symptom of the disease. They're so busy weaving corporate/government conspiracy theories that they can't see that the science is neutral, and tools like the buckyball can be used to further their own agendas -- like treating and curing diseases in developing nations.

Then, of course, the argument degenerated into a tug-of-war (I captured images of the event using my Motorola camera phone, above). "Buckyball bad," Thurston said. "Buckyball good," I said. "Buckyball bad," Thurston said. "Buckyball good," I said. ...

It continued like that for a while until I finally tossed the buckyball around the yard a few times, he fetched it a few times, I gave him a treat and the incident was forgotten. Thurston may be a bit misinformed, but he's really a good boy.

Related Posts
Virtual villagers with pitchforks
A little story about drugs, bass and balls
Too late to stem the 'toxic bucky' tide

Saturday, May 29, 2004

Safety and health group launches nano page


The National Institute for Occupational Safety and Health has launched a Safety and Health Topic page on nanotechnology. Here's what the institute says under "Occupational Health Risks."

    Occupational health risks associated with manufacturing and using nanomaterials are not yet clearly understood. The rapid growth of nanotechnology is leading to the development of new materials, devices and processes that lie far beyond our current understanding of environmental and human impact. Many nanomaterials and devices are formed from nanometer-scale particles (nanoparticles) that are initially produced as aerosols or colloidal suspensions. Exposure to these materials during manufacturing and use may occur through inhalation, dermal contact and ingestion. Minimal information is currently available on dominant exposure routes, potential exposure levels and material toxicity. What information does exist comes primarily from the study of ultrafine particles (typically defined as particles smaller than 100 nanometers).

    Studies have indicated that low solubility ultrafine particles are more toxic than larger particles on a mass for mass basis. There are strong indications that particle surface area and surface chemistry are primarily responsible for observed responses in cell cultures and animals. There are also indications that ultrafine particles can penetrate through the skin, or translocate from the respiratory system to other organs. Research is continuing to understand how these unique modes of biological interaction may lead to specific health effects.

    Workers within nanotechnology-related industries have the potential to be exposed to uniquely engineered materials with novel sizes, shapes and physical and chemical properties, at levels far exceeding ambient concentrations. To understand the impact of these exposures on health, and how best to devise appropriate exposure monitoring and control strategies, much research is still needed. Until a clearer picture emerges, the limited evidence available would suggest caution when potential exposures to nanoparticles may occur. More here.

For more background, take a look at the May 19 Small Times' report on this subject.

Thursday, May 27, 2004

Virtual villagers with pitchforks


Buckyballs, brain-damanged fish, Swiss insurance, toxic ignorance, the whole zoo is getting a thorough Slashdotting. Next come the villagers with torches and pitchforks. Oh well. Remember, though, you read it all in Small Times first.

Wednesday, April 07, 2004

A little story about drugs, bass and balls


didn't make me wait very long to find an illustration of a point I made last week in Washington.

Big Concern for Very Small Things (Get it? The concerns are "big," yet the technology is "small.") mentions the Nanodesu bowling ball as "one of the first consumer products that uses nanoparticles called fullerenes -- aka buckyballs. ..." (These beauties come come in regular and "1500").

The reporter rolls out the balls, however, as merely a transitional vehicle to get to where he really wanted to go: From apples to oranges to, yes, fish. Our poor, brain-damaged bass who likely will never see retirement as long as Google News exists.

This seems like a good opportunity for a transition of my own to a conversation I had last week with Clayton Teague, director of the National Nanotechnology Coordination Office (NNCO). It's going to be his job to handle "public outreach" for the U.S. government's nanotech program. In this conversation, I present a scenario similar to the one Wired so nicely illustrated for me, only I used the example of buckyballs as drug-delivery device rather than as angel of 10-pin death.

Here's a peak into the middle of our hour-long conversation (these are some pretty raw notes, so forgive the typos):

    Howard Lovy: There's a difference between chemicals that are bad for you in any size, are toxic whether they're nanometer-size or not …

    Clayton Teague: Yes, arsenic -- it doesn't matter whether it's 1 micrometer or a tenth of a nanometer. It's bad for you.

    HL: But what's not understood is the effect of some of these new engineered nanoparticles and what happens when it's ingested or breathed in, or what happens when it passes through the blood-brain barrier. That's what's not understood.

    Teague: Let me just make one other point there. There's also a difference between, as you say, exhaust nanoparticles, or abrasive nanoparticles and some of the new engineered nanoparticles. There, if you took even nanometer-scale asbestos. It may have some dimensions that are nanoscale, but it's very highly uncontroled sizes, the surface chemistry is different, the aspect ratios are different.

    If I go to a buckyball. Every one of those buckyballs is nearly identical. They may conglomerate and form a different shape when they come together, but their surface chemistry and they way they look is like a highly uniform collection. They're very monodispersed. They're very highly uniform in character, in dimension, chemical surface property and things like that. So, that's why, in some instances they're functioning completely different, but it also may mean that their interaction with the body might be very different because they have this very nice, different surface chemistry and are very monodispersed in size. So, when we say they may be different in the body, they may be different in the body.

    HL: Well, that's what's confusing, then, because scientists want to use the buckyball for a drug-delivery device because of it's special properties. At the same there are FDA trials involving buckyballs there are toxicity studies involving buckyballs.

    Teague: Exactly. They're all going on.

    HL: So, to the general public first being introduced to buckyballs, which do they pay attention to? Are they wonderful drug-delivery devices or are they potentially toxic, or both?

    Teague: That's right. They could be. But until we have data, we have really honest-to-goodness data, we have no basis for a decision. As you were talking about earlier, people can get very afraid, but the FDA is not going to approve those as a drug-delivery device until their data can substantiate that they are not going to be harmful to the body.

    HL: Being a former general-interest journalist, here's how I can see things happening: The FDA comes out with something about buckyballs as a drug-delivery device. A reporter on the science desk at the Podunk Journal is asked to do a story on it. He does a LexisNexis or Google search, sees that story about the buckyballs and fish, and ties the two together. Then you've got another public relations problem.

    Teague: I think that's a very realistic scenario. Somehow it has to be communicated to people that fish and mammals don't react in the same way. That's one thing. How you get those kinds of things across in a valid way without sounding like we're trying to whitewash something is (pause). I think you have to be just as factual as you can (another pause). I don't know how else to deal with it, other than trying to be factual as you can and saying fish and mammals are different, you breathing something is different from you swallowing something as the fish does.

    HL: I don't envy your job. These are the issues you're going to be dealing with.

Discuss


Monday, April 05, 2004

Too late to stem the 'toxic bucky' tide


From tidepool.org, more evidence that the environmental activist community is picking up the buckyball story and running with it. Ed Hunt writes:

    Western states are hoping to cash in on the next big technological boom - nanotechnology. Billions of dollars are being invested into what is likely to become a global trillion-dollar-a-year industry.

    Yet what are the consequences of this new industry to the people of Salmon Nation? What are the potential problems for salmon, and the other creatures that live here?

    … Few studies on health or environmental effects of nanoparticles have been conducted. Of the studies that have been conducted, the results have not been encouraging. Indeed, nanoparticles appear to have negative -- toxic -- effects on metabolism in ways that scientists did not anticipate. Almost no testing has been conducted to study the most likely vector for nanopartical contamination. Studies where nanoproducts are inhaled are expensive. Thus far, no one has expressed any interest in funding them, according to the Washington Post.

    Moreover, some of the new nanoproducts being created are proprietary and so the companies creating them do not want to disclose what they contain even when they plan to release them into the environment.

    Why should we in the Pacific Northwest be concerned about this lack of regulatory oversight applied to this potentially lucrative field?

    Because our states are spending millions of state taxpayer dollars in the hopes of attracting billions of federal taxpayer dollars to foster an industry with -- by all accounts -- unknown health and environmental consequences. I'm a life-long subscriber to Popular Science and a technology evangelist, but that makes even me nervous.

You can read the rest here. This piece, which is certainly not knee-jerk neoluddite, nevertheless does begin with the assumption that buckyballs are bad – a premise that was based solely one very limited study that even the researcher says should not be taken out of context. Of course, it has been and will continue to be. I asked Commerce Undersecretary Phil Bond about this last week in Washington.

Howard Lovy: Do you think it's almost too late? What was retained, and spread around the world, was "buckyballs, toxicity."

Phil Bond: "Buckyballs kill fish."

HL: Right. It's simplistic, but that is how these things spread around the world then is filtered through people's own personal politics and worldview.

Bond: Is the damage done, you mean?

HL: Is the damage done, but also wouldn't the people who want to be receptive to "bad nano" find something else?

Bond: Well, I suspect that that may be true. There are early adopters to any technology, both pro and con. So, the early adopters in the con view are not going to be persuaded. They're already convinced and they will take stories like this as proof of their point of view. However, I think the vast majority of people, certainly in the United States, are positively predisposed toward new technology as things that can both make life better and create jobs.

HL: Do you think that could change, though, as it did in Europe – where bad information actually hindered the genetically modified foods industry.

Bond: Yes, it can. I'm not sure in my lifetime I can see the fundamental attitude changing, but it can slow us down while we have the discussion, we can lose leadership while you're having the discussion.

HL: They're already protesting outside Lawrence Berkeley.

Bond: Right, I think you can certainly slow things down. I think America is still almost genetically positive about technology and innovation as a way to make life better and so we need to harness that and put it to use and at the same time addressing legitimate concerns.

Related Posts
Commerce's call to nano arms
Nano is a concept by which we measure our pain
A sad jab at the 'Bad Rad Lab'

Discuss

Sunday, March 28, 2004

Nano is a concept by which we measure our pain


Toxicologist Eva Oberdorster's new study on the effects of nanoparticles on aquatic animals deserves some thoughtful analysis, yet the Washington Post makes some strange leaps of logic in its reporting.

    The study, described at a scientific meeting Sunday, was small and has yet to be peer reviewed or published in a scientific journal. And although some companies anticipate making tons of the particles within the next few years, current production levels are relatively low, so the risk of exposure for humans and other animals is still quite small.

    Nonetheless, the findings underscore the growing recognition that the hot new field of nanotechnology, which federal officials have said will be at the heart of America's "next industrial revolution," may bring with it a number of old-fashioned trade-offs in terms of potential environmental damage and health risks.

    Other animal studies have already suggested that a related class of nanoparticles cause lung injuries when inhaled, raising concerns about worker safety in the small but growing number of nanoparticle factories.

Sorry, but the qualifiers "may" and "suggested" just do not do enough to counteract the impression left on the reader that nanoparticles cause lung injuries and threaten factory workers.

As I've pointed out before, the "animal studies" mentioned above concluded that if you pump rats' lungs full of nanotubes, they will suffocate. The toxicity of the nanoparticles was not conclusive and, in fact, it was suggested that the clumping was a good sign, since it prevented the nanotubes from reaching deeper into the lungs.

The vague idea of some future "factory workers" being endangered is mentioned once, then dropped.

While it would be foolish for nanotech businesses and advocates in government to dismiss concerns over "nanotox," all parties need to stick to the evidence as it's presented. This latest study is yet another small piece of evidence in a longer process of scientific discovery. Despite the tendency of the media to want to tell its readers what these small-scale studies mean by making all sorts of unscientific leaps in logic for them, don't lose sight of what is actually being presented.

Some better context can be found in The New York Times' coverage:

    "This is a yellow light, not a red one," Dr. Oberdorster said in a telephone interview last week.

    Vicki L. Colvin, whose laboratory at Rice University's Center for Biological and Environmental Nanotechnology supplied the buckyballs used by Dr. Oberdorster, was even more cautious about the results, which have not yet been reviewed by other scientists.

    Dr. Colvin said that the surface characteristics of the lab's buckyballs, which are not a form that is commercially available, needed further study. She said that they had not been coated, a process that is commonly used to limit the toxicity of such materials in applications like drug delivery.

Nanotechnology is such a young discipline that any issue for which the nano name is invoked is largely a reflection of a personal world view or political agenda rather than any overwhelming body of evidence. Nanotechnology advocates in business and government choose to focus on the optimistic leaps of logic, while those who see corporate conspiracies in the wallpaper can make just as many plausible or implausible leaps into the negative. As I told Neofiles a few months ago:

    A health advocate could say that once nanoparticles breach the blood-brain barrier, we're entering into dangerous territory, while another can say that breaching that barrier will enable a range of cures for various brain disorders. Nanotechnology, right now, is an unsettled wilderness that is either abundant with resources for the picking, or a vast frozen wasteland. It's a reflection of your own world view.

Right now, the general public is being bombarded with some amazing predictions of how nanotechnology will completely alter almost every aspect of their lives. To many, the claims seem not only fantastic, but implausible. Nanotech proponents in government and business are just as guilty of promoting selective logic as the neoluddites of the environmental movement when they ask the public to believe positive implausible scenarios and not to pay attention to the negative.

It's a difficult concept to describe. I was asked by a reporter for NPR's "Marketplace" last week to define nanotechnology. I gave the usual explanation (under-100-nanometers, special-properties, etc.), and then I struggled to explain how nanotechnology right now is more of a concept than anything else. We've created the building blocks and dumped them on the floor. What we create with them now, and how safely we do it, is yet to be determined.

So, there is nano the science and nano the business, and they're moving along quite nicely as they take their baby steps. But when it reaches level of public debate, nano often loses its solidity to become neither science nor business, but a concept that is a reflection of the human imagination.

Related Posts
Nanotubes and the tale of the rats
The nano-brain barrier
New materials are not without risk

Discuss


Monday, January 19, 2004

Nano's 'No GMO' Mantra

It's obvious that business and government have a bad case of DNA PTSD, or genetic shell shock, which is why they certainly won't get fooled again when it comes to nanotechnology. I've heard the mantra many times during the past few years: "No More GMO." But the chanters wear pinstripes and not patchouli oil.

Public outcry (especially in Europe) against genetically modified organisms was the result of a determined effort between science, business and government to completely misread the public. It took some serious brainpower, collusion and planning to so totally miss the point on what gets the masses all fired up, and the important role public perception plays in the introduction of any new technology. The biggest mistake was the arrogant assumption that the public will accept as inherently good anything that helps big biotech companies succeed and farmers increase their yields. What was missing from the equation, of course, was consideration of how the public "feels" about genetic manipulation.

The right has a problem with "playing God," while the left doesn't want the corporate world messing with Mother Nature. The result is that it could take a generation or two to undo the damage done to public acceptance of scientific progress.

If you're curious about how and why this happened, PBS is running an excellent series on the history of DNA, and last night I caught some of the episode that deals with genetically modified organisms. The PBS site's "gallery of genetic modifications" is especially well done, stating the issues concisely and with flair.

It goes into the Flavr Savr tomato, created by the biotechnology company Calgene, and accompanying "rumors and horror stories [that] mention square tomatoes or tomatoes that glow in the dark."

By the time the Human Genome Project came along in the late '90s, the lesson had been learned. That's when the phrase "societal and ethical implications" became part of the government lexicon.

I recently had a talk with Kevin Ausman, executive director of the Center for Biological and Environmental Nanotechnology at Rice University, who explained some of this historical context to me.

The study of societal and ethical implications, he said, is now an embedded part of most government nanotechnology programs, and it's a direct descendent of the Human Genome Project, where science, government and business had amazingly learned from their mistakes.

"The scientists involved in the Human Genome Project weren't really aware, until lots of surveys and things were done by the social scientists, that privacy issues were going to be the public hot-button issue," Ausman said. "In hindsight it makes a lot of sense."

And it paid off in broader public acceptance and trust. "You do a comparison of the Human Genome Project to genetically modified organisms, and it's just incredible the difference in public perception, and I believe pretty strongly that's directly attributable to the money and the good-faith effort that went into studies about societal and ethical implications," he said.

One more thing about DNA on PBS that I think could echo into nanotech's future. The documentary describes the "golden rice" debacle in which Monsanto essentially made overblown claims that it has found the solution to malnourishment. Long story short: "According to a 1999 report in the Financial Times, African countries in particular are 'wary of increasing dependence on developed countries and multinational corporations as a result of genetically modified crops.'"

A number of efforts are about to get under way that involve selling the idea of nanotechnology to developing nations, including those in Africa, as a means of solving local problems. Nanotechnology proponents are telling them that nano is no GMO. There doesn't need to be a Great White Monsanto to dole out its product. Developing nations can grow their own nanotech industry and tailor it to their own needs. It's true, but nanotech proponents will first need to penetrate more than a few layers of mistrust.

Watch for some of these efforts to make the news this year.

Related Posts
The Napster of nano
A nanosize line in the sand
Water for peace

Discuss

Thursday, January 08, 2004

Nanotubes and the tale of the rats


This Reuters report on how nanotubes will kill you (if you're a rat) was a prelude to Nanotox 2004 next week in the U.K. The news conference was a way to generate some media buzz in advance and get reporters all jazzed up over an event at the Royal Microscopical Society. Of course, Small Times' man in London will be there, so you can expect some first-rate reporting, with proper context.

The British scientists, meanwhile, were telling rat tales, pointing to DuPont toxicologist David Warheit's recent study on the toxicity of single-wall carbon nanotubes in rats.

Yes, it's DuPont that did the study, so you can read what you want into it, but the Center for Biological and Environmental Nanotechnology (CBEN) at Rice University had also looked at the results.

I'll cut to the chase on the tale of the rats.The study concludes, in part:

rat

    "Exposures to high-dose (5 mg/kg) SWCNT produced mortality in ~15% of the SWCNT-instilled rats within 24 h postinstillation. This mortality resulted from mechanical blockage of the upper airways by the instillate and was not due to inherent pulmonary toxicity of the instilled SWCNT particulate."

Kevin Ausman CBEN's executive director, supplied me with a wonderfully understandable translation during a conversation I had with him a month ago in Chicago:

    What that means is that if you look at just the cross-sections of the lungs, "Uh-oh. Bad things are happening." If you look at the biochemistry of what's going, almost nothing seems to be going on. And so the normal biochemical tags for, "something bad is happening" aren't telling something bad is happening."

Here's my translation of the translation: The rats were definitely dead (and I believe they are still dead, although I have yet to confirm this). The nanotubes were definitely the guilty party. But the late rodents met their rat makers by suffocation, and not necessarily from any poison in the tiny tubes.

Plus, what the researchers did, as Ausman explained it to me, was basically disperse the nanotubes into a soap-and-water solution and inject it into the lungs, avoiding the whole issue of how the nanotubes ever got there in the first place.

This is how science works. Small steps, each study building on the conclusions of others. Nanotubes might, as the slogan goes these days, turn out to be the "next asbestos," but it is far too early to convict them of anything except being in the wrong rats at the wrong time.

For more on DuPont and nanotubes, here's an excellent report from The News Journal of Delaware. And more background can be found on Small Times here and here.

Monday, July 28, 2003

Subterranean Nano Blues


"Hey, lay off Greenpeace," my wife told me over the weekend. "They're not PETA, and they do a lot of good – more good than you do, just sitting behind your computer and writing."

My wife, of course, is both my biggest fan and my biggest critic and rarely pulls punches.

Aside from the fact that she's my wife (and thus, always right), she does have a very good point. Greenpeace does do a great deal of good in the world, and of course it does not just sit in an office and pontificate. Its members physically place themselves in harm's way to draw attention to important environmental issues. That's the activism my wife grew up with. She was raised by '60s radicals who today have lost none of their youthful idealism (displayed in their home is a great picture of my in-laws, circa '70s, in full hippie regalia, at a no-nukes march in Washington with my future wife by their side).

So, yeah, my in-laws must think their daughter married a total sellout. (To add insult to injury, I was also one of those liberals who was in favor of overthrowing Saddam Hussein, but of course that subject goes beyond the mission of this blog).

Like I told my friend and faithful Small Times correspondent Jack Mason, in an interview he conducted with me for an article he's writing for Salon (I'll let you know when it runs. We all need to help that excellent online magazine survive), I feel horrible over the possibility that the industry I'm covering is about to be painted with a broad "polluter" brush – especially when what is known about nanotech's potential benefits to the environment outweigh what is not known.

I have covered local environmental issues during my reporting career, and one thing that I've remained curious about is the idea of risk – the "acceptable" risks we take just commuting to work, vs. the risks associated with, for example, living near a trash incinerator or close to power lines. We make decisions every day about which risks we deem acceptable (or choose to ignore), and which ones we worry about. I've read reports from environmental watchdogs on the local and national levels that assessed various health risks associated with a NIMBY issue, and I've read some ridiculous counterarguments from the "pro-industry side" that compare these risks to the chances of exposure to random horrors by just leaving our house. Usually, both these arguments lack common sense.

What Greenpeace is invoking for nanotech is what they used in previous battles, the Precautionary Principle, which essentially says that we're better safe than sorry. It reduces the possibility of horrible mishaps by limiting scientific exploration when safety is in doubt. In general, I'm in agreement with the principle. It makes perfect sense – if the safety of a technology is in doubt.

The trouble is that Greenpeace is too early on this. Nanotech's safety isn't "in doubt." We don't know enough about the behavior of nanoparticles in our bodies and in the environment to even have a doubt. The Precautionary Principle could reasonably be invoked after we know more about specific nanomaterials under specific conditions. Then, the alarm bells can go off, and Greenpeace can do what they do best: Call attention to the potential problem and demand action.

To Greenepeace's credit, the group did conclude its report with a brief nod to the "number of environmental goods that may arise" from nanotechnology and a call for "a more in-depth analysis of environmental concerns."

A couple of excellent articles on this general topic moved in today's news cycle. Take a look at Fear of the science of the small 'is focused on the wrong things', from the Guardian, and this one from EurekAlert, Nanotechnology: sink or swim?

Now, I hope when we visit this weekend, my in-laws will let me out of the chicken coop and allow me to sleep in the house.

Discuss

Friday, July 25, 2003

The Greenpeace Report, Part II: NanoWars


It is said that military leaders are perpetually fighting the previous war. The same can be said of the rainbow warriors, Greenpeace, whose recently released opening shot at nanotechnology is really a battle plan for the environmental activist group's previous conflict against genetically modified foods.

It's clear that Greenpeace is choosing to ignore some important landscape differences between the old GM foods battlefield and the theater of operations in the coming war over nanotechnology. In its report, Future Technologies, Today's Choices, Greenpeace misidentifies the conditions under which the science of nanotechnology is now growing.

Greenpeace has decided that the label "nanotechnology" is merely the latest incarnation of an industrial system that allows the very few and very mighty to hand down decisions from on high for the sole purpose of enriching themselves at the expense of the masses. Greenpeace does not see nanotechnology for what it is: a broad label for a very sophisticated kind of science or process that can help accomplish any number of technological goals. Whether those goals include environmental cleanup or more-efficient killing machines is the choice of the broader society.

Doug Parr, Greenpeace's chief scientist, writes in the report that if there are unintended consequences of a new technology, "it is unreasonable to expect collective responsibility if the decision to proceed with the technology was made by an elite few." He goes on to write, "… the interests of those who own and control the new technologies largely determine how a new technology is used."

Who are the "elite few"? He really doesn't say. I suppose that's a wink and nod to his intended audience, which I assume already knows who these elite people are. Later, the report states that nanotech "materials and processes being developed are technology-pushed rather than market-led."

Well, meanwhile, in the world of real nanotechnology, the few products that have been successful in the marketplace (take a look at my previous post) are those that fill a consumer or market need. The oft-repeated examples of stain-free pants and sunscreen are successful not because they are products dictated from on high, but rather are driven by consumer demand.

That's not to say that the "elite few," if given the chance, wouldn't love to tell consumers what's good for them. If by "elite," Greenpeace means the nanotech scientists hatching their evil plans at university and government labs, the group could take comfort in knowing that many of these scientists remain frustrated that investors and consumers are not immediately opening up their wallets to any contraption that emerges from their head and into a prototype.

Greenpeace's report is correct when it asserts that "some new materials may constitute new classes of non-biodegradable pollutant about which we have little understanding," and that "little work has been done to ascertain the possible effects of nanomaterials on the living systems, or the possibility that nanoparticles could slip past the human immune system."

Nanotech researchers will be the first people to admit this, and at institutes like the Center for Biological and Environmental Nanotechnology at Rice University, they're eagerly learning the answers to these important questions. If they discover that horrible things happen to the body when nanomaterials are introduced, yet these materials are still placed on the market without consumers' informed consent, then I'll be right there alongside Greenpeace in demanding their removal. In the meantime, let the discovery process continue.

The Greenpeace report does establish a good framework for the debate over societal implications to nanotechnology, especially when it poses important questions that we all should be asking. Among them: "Who is in control? Where do the benefits fall? Who takes responsibility for resulting problems?"

But Greenpeace's implied answers to these questions again can be applied to the old GM foods battlefield, but not universally to nanotechnology.

"Who is in control?" Well, right now, consumers are. They decide what they'll buy, thus influencing what investors will pay to develop. Genetically modified foods, in contrast, were in many cases thrust on consumers without their informed consent. The report contrasts this with the mobile phone industry, where consumers gladly ignored the unknown risks associated with them in favor of the convenience they provided. Mobile phone buyers know what they're doing, know that there is a shortage of research on their long-term health effects, and went ahead and supported the industry, anyway. A cabal of elite companies did not force feed it on anybody.

Where do the benefits fall? That's a political question that has no correct answer. If you believe that it's a bad thing for small companies to become so successful at selling to consumers that they turn into big companies, then you've already answered the question before it's even asked.

Who takes responsibility for resulting problems? I'll translate this question for you: "Who should the angry mob blame when the technology is perceived to have gone awry?"

Throughout the report, a distinction is drawn between "science" and "society," without any definition of who or what those entities are, leaving us with the assumption that they are inherently at odds, rather than enjoy a symbiotic relationship – one influencing the other through changing consumer habits, varying states of war and peace and the pace of scientific discovery. When Greenpeace talks of a possible "dystopian future" where "the shift of the control of nanotechnology" turns toward "military needs," it dismisses the well-established give-and-take relationship between military and consumer technology.

Of course, the message here – with wording tailored to the audience – is that "war is bad." Yes, of course. War is bad. Our military and political leaders should really get together and try to stop all wars. Now, what does that have to do with nanotechnology?

Nanotech is a process, a tool, a way of building and improving practically anything we want. The focus of our worldwide discussion of "societal implications" should be about the way we want to build our society, and not about the inherent evil or goodness of the hammers and nails we're going to use to build it.

Greenpeace asks, rhetorically for internal consumption: "Is the future of nanotechnology then a plaything of the already-rich?" Well, not if the ultimate goals involve better, cheaper, nonpolluting products and energy available to everybody. If that is what consumers, leaders and scientists decide, then nanotech is there to help. The nanotech battle should really be fought for the hearts and minds of consumers and voters, and not against the technology itself.

Greenpeace begins with the assumption that average people are powerless against invisible forces that secretly control society's agenda (it's where the political left always meets the right), without acknowledging that these "forces" cannot remain entrenched in the face of a society that rejects them. America is obese? Don't blame McDonald's. The Golden Arches can't survive without a public willing to march into their death chambers.

You want nanotechnology that doesn't make a mess of what's left of our planet? I think that's a great idea. Let's bring on the global discussions over how we're going to get there. But it's not a question of "good nano" or "bad nano." It's a question of how we're going to use nano.

Discuss

Thursday, July 24, 2003

Nanotechnology industry takes Greenpeace's bait


Greenpeace's just-released report on nanotechnology is vintage advocacy-group treatment of scientific research: Grab the available facts, then make them conform to your predetermined conclusion. That, after all, is what advocacy groups do. And most intelligent readers are able to keep that in mind when they come across any "study" that comes out of an organization that filters information through its preset worldview.

It's true for Greenpeace, the National Rifle Association or the Save the Bog Turtle Foundation.

Having worked in the news business most of my life, I've read through countless advocacy-group studies and have become fairly adept at separating the slogans and code phrases from the legitimate conclusions. Read enough of these research reports from groups with competing agendas, and a complete picture emerges not only of the facts that govern the issue, but more importantly how the actors involved process information and reach their conclusions.

A report like this one from Greenpeace, no matter its scientific merit, is an important read for everyone concerned about nanotechnology's future because it's a window into how the organization filters its information. Understanding – not necessarily agreeing, but understanding – can go a long way toward developing strategies to avoid ugly public confrontations like the battles over genetically modified foods. Greenpeace is a potentially powerful worldwide thought leader that can have a huge influence over public opinion, and the nanotech industry ignores or belittles it at its own peril.

That's why I was quite surprised at the reaction of NanoBusiness Alliance Executive Director Mark Modzelewski to this report. He attacked it as “industrial terrorism," telling Small Times correspondent Douglas Brown, "It’s a great way to raise new funds and pretend they care about something. The reason these groups care about nanotechnology is because they view it as the next industrial revolution. And, to them, slowing it down, creating fear and upsetting people is their means of creating a choke point on the development of industry and technology. They saw how it worked on genetically modified foods, and so this is a great way for them to do the exact same thing.”

Not a very astute way of representing nanotech as a responsible industry that takes public opinion into account. Modzelewski's comments, in fact, conform perfectly to Greenpeace's hard-wired view of industry – no matter what industry – as inherently irresponsible and self-interested, in need of watchdogs to keep them in check.

In fact, the report states right near the front that nanotech business alliances worldwide have been formed for the sole purpose of translating research into products and to build enough momentum behind the industry that any attempts to put the brakes on it as a result of public debate or input would be irrelevant. Enter Modzelewski, right on cue, seeming to confirm that the nanotech industry is dead set against any kind of slowdown or pause to think about the long-range impact of what it's doing.

That may not have been his intent, but it will be the way Greenpeace interprets the industry's initial reaction to environmental concerns and could set the tone for the debate to come.

In the next post, I'll analyze the Greenpeace report, itself. For now, though, I'll give you a hint: Take out the code words and phrases that are tailored to Greenpeace's audience, and you'll find some sound advice in there for the nanotech industry. As I've written previously, public perception is of paramount concern to anybody who cares about the future of nanotechnology.

Discuss