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G-quartets 40 years later: from 5'-GMP to molecular biology and supramolecular chemistry Davis JT Angew Chem Int Ed Engl. 2004 Jan 30; 43(6): 668-98 Molecular self-assembly is central to many processes in both biology and supramolecular chemistry. The G-quartet, a hydrogen-bonded macrocycle formed by cation-templated assembly of guanosine, was first identified in 1962 as the basis for the aggregation of 5'-guanosine monophosphate. We now know that many nucleosides, oligonucleotides, and synthetic derivatives form a rich array of functional G-quartets. The G-quartet surfaces in areas ranging from structural biology and medicinal chemistry to supramolecular chemistry and nanotechnology. This Review integrates and summarizes knowledge gained from these different areas, with emphasis on G-quartet structure, function, and molecular recognition. More Paranemic crossover DNA: a generalized Holliday structure with applications in nanotechnology Shen Z, Yan H, Wang T, Seeman NC J Am Chem Soc. 2004 Feb 18; 126(6): 1666-74 The key feature of the structure is that the two adjacent parallel DNA double helices form crossovers at every point possible. Hence, reciprocal crossover points flank the central dyad axis at every major or minor groove separation. More Discuss You click, you buy DNA's Debut Cracking the Genome: Inside the Race to Unlock Human DNA